Gupta, P. D. ; Swarup, G. ; Reddy, A. G. (1990) Modulation of phosphorylation and dephosphorylation of keratin and other polypeptides by estradiol-17β in rat vaginal epithelium FEBS Letters, 273 (1-2). pp. 135-138. ISSN 0014-5793
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Official URL: http://www.sciencedirect.com/science/article/pii/0...
Related URL: http://dx.doi.org/10.1016/0014-5793(90)81068-Y
Abstract
Phosphorylation of keratin polypeptides was studied by incubating vaginal tissues (removed from estradiol primed and unprimed 30-day-old rats) with 32Pi. Analysis by SDS-PAGE and autoradiography showed that on treatment with estradiol phosphorylation of 63 and 58 kDa keratin polypeptides increased 3-and 2-fold respectively. Phosphorylation was maximal after 30 min of estradiol priming and decreased thereafter. Phosphorylation of some non-keratin polypeptides (37, 34, 32 and 25 kDa) also showed time dependent variation. The results showed that estradiol can modulate phosphorylation-dephosphorylation of keratins and other polypeptides in rat vaginal epithelial cells.
| Item Type: | Article |
|---|---|
| Source: | Copyright of this article belongs to Elsevier Science. |
| Keywords: | Phosphorylation; Dephosphorylation; Estradiol; Keratin; Vaginal Epithelium |
| ID Code: | 55937 |
| Deposited On: | 19 Aug 2011 07:54 |
| Last Modified: | 19 Aug 2011 07:54 |
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