Subba Rao, G. S. R. ; Kondaiah, Paturu ; Singh, Sanjay K. ; Ravanan, Palaniyandi ; Sporn, Michael B. (2008) Chemical modifications of natural triterpenes-glycyrrhetinic and boswellic acids: evaluation of their biological activity Tetrahedron, 64 (51). pp. 11541-11548. ISSN 0040-4020
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Official URL: http://www.sciencedirect.com/science/article/pii/S...
Related URL: http://dx.doi.org/10.1016/j.tet.2008.10.035
Abstract
Synthetic analogues of naturally occurring triterpenoids; glycyrrhetinic acid, arjunolic acid, and boswellic acids, by modification of A-ring with a cyano- and enone-functionality, have been reported. A novel method of synthesis of α-cyanoenones from isoxazoles is reported. Bioassays using primary mouse macrophages and tumor cell lines indicate potent anti-inflammatory and cytotoxic activities associated with cyano-enones of boswellic acid and glycyrrhetinic acid.
| Item Type: | Article |
|---|---|
| Source: | Copyright of this article belongs to Elsevier Science. |
| ID Code: | 55717 |
| Deposited On: | 19 Aug 2011 03:36 |
| Last Modified: | 19 Aug 2011 03:36 |
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