Chitnis, Chetan E. ; Sharma, Amit (2008) Targeting the Plasmodium vivax duffy-binding protein Trends in Parasitology, 24 (1). pp. 29-34. ISSN 1471-4922
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Official URL: http://linkinghub.elsevier.com/retrieve/pii/S14714...
Related URL: http://dx.doi.org/10.1016/j.pt.2007.10.004
Abstract
Plasmodium vivax requires interaction with the Duffy antigen receptor for chemokines (DARC) to enable its invasion of human erythrocytes. Interaction with DARC is mediated by the P. vivax Duffy-binding protein (PvDBP) and is essential for junction formation, which is a key step in the invasion process. The receptor-binding domain of PvDBP maps to a conserved cysteine-rich region, referred to as region II (PvRII). Here, we review data on the interaction of PvRII with DARC and explore the potential of targeting this crucial receptor-ligand interaction to develop new intervention strategies against P. vivax.
| Item Type: | Article |
|---|---|
| Source: | Copyright of this article belongs to Elsevier Science. |
| ID Code: | 5562 |
| Deposited On: | 19 Oct 2010 11:54 |
| Last Modified: | 15 Jul 2012 14:37 |
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