Efficient ring opening of aziridines with carboxylic acids

Kumar, Manoj ; Gandhi, Shikha ; Kalra, Swinderjeet Singh ; Singh, Vinod K. (2008) Efficient ring opening of aziridines with carboxylic acids Synthetic Communications, 38 (10). pp. 1527-1532. ISSN 0039-7911

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Official URL: http://www.tandfonline.com/doi/abs/10.1080/0039791...

Related URL: http://dx.doi.org/10.1080/00397910801928723

Abstract

An efficient ring cleavage of aziridines with acids has been studied in the absence of any catalyst. The hydrolysis of the products, amino esters, leads to the corresponding amino alcohols. The reaction has been extended to chiral cycloalkyl aziridines, leading to the formation of diastereomers. After separation, these diastereomers have been converted to optically pure amino alcohols in two steps.

Item Type:Article
Source:Copyright of this article belongs to Taylor and Francis Group.
Keywords:Amino Alcohols; Amino Esters; Unactivated Aziridines
ID Code:55429
Deposited On:18 Aug 2011 08:45
Last Modified:18 Aug 2011 08:45

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