Raj, Monika ; Vishnumaya, ; Ginotra, Sandeep K. ; Singh, Vinod K. (2006) Highly enantioselective direct aldol reaction catalyzed by organic molecules Organic Letters, 8 (18). pp. 4097-4099. ISSN 1523-7060
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Official URL: http://pubs.acs.org/doi/abs/10.1021/ol0616081
Related URL: http://dx.doi.org/10.1021/ol0616081
Abstract
We have demonstrated that a new class of L-proline-based organic compounds catalyzed the direct aldol reaction between aldehydes and acetone to provide β-hydroxy ketones in good yields. The reaction is efficient, and 5-10 mol % of the catalyst and excellent enantioselectivities (97-99% ee) were obtained in both aromatic and aliphatic aldehydes. The presence of a gem-diphenyl group at the β-carbon is necessary for high enantioselectivity.
| Item Type: | Article |
|---|---|
| Source: | Copyright of this article belongs to American Chemical Society. |
| ID Code: | 55411 |
| Deposited On: | 18 Aug 2011 08:43 |
| Last Modified: | 18 Aug 2011 08:43 |
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