Srinivas, Oruganti ; Mitra, Nivedita ; Surolia, Avadhesha ; Jayaraman, Narayanaswamy (2002) Photoswitchable multivalent sugar ligands: synthesis, isomerization, and lectin binding studies of azobenzene-glycopyranoside derivatives Journal of the American Chemical Society, 124 (10). pp. 2124-2125. ISSN 0002-7863
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Official URL: http://pubs.acs.org/doi/abs/10.1021/ja0173066
Related URL: http://dx.doi.org/10.1021/ja0173066
Abstract
Coating of azobenzene chromophore with multivalent sugar ligands has been accomplished. Such sugar coating allows the study of the isomerization properties of this chromophore in aqueous solutions. The predominantly cis-isomer-containing photostationary state (PS) mixture of these azobenzene derivatives is found to be stable for hours. The rate constants for their isomerization, as well as the Arrhenius activation energies, are determined experimentally. An assessment of the lectin binding properties of the lactoside bearing isomeric azobenzene derivatives, by isothermal calorimetric methods, reveals the existence of an unusual cooperativity in their binding to lectin peanut agglutinin. Thermodynamic parameters evaluated for the trans and the PS mixture are discussed, in detail, for the lactoside bearing bivalent azobenzene derivative.
Item Type: | Article |
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Source: | Copyright of this article belongs to American Chemical Society. |
ID Code: | 55372 |
Deposited On: | 18 Aug 2011 12:04 |
Last Modified: | 15 Jul 2012 10:38 |
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