Rout, Pramod K. ; Vrati, Sudhanshu (1997) Oral immunization with recombinant vaccinia expressing cell-surface-anchored βhCG induces anti-hCG antibodies and T-cell proliferative response in rats Vaccine, 15 (14). pp. 1503-1505. ISSN 0264-410X
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Official URL: http://www.sciencedirect.com/science/article/pii/S...
Related URL: http://dx.doi.org/10.1016/S0264-410X(97)00094-7
Abstract
A vaccinia recombinant, VSS2, expressing cell-surface-anchored β-subunit of human chorionic gonadotropin (βhCG) has earlier been found to induce high titered anti-hCG antibodies in rats immunized by tail scarification. The immunogenicity of this recombinant was compared in rats which received the virus through different routes of inoculation: intradermal, intragastric, intrajejunal or by tail scarification. The recombinant virus induced high titers of anti-hCG antibodies in all instances although the titers were about one log lower when the recombinant virus was delivered orally. The recombinant was found to induce T-cell proliferative response in rats of all immunization groups.
| Item Type: | Article |
|---|---|
| Source: | Copyright of this article belongs to Elsevier Science. |
| Keywords: | VSS2; Immunocontraception; Immunogenicity |
| ID Code: | 55120 |
| Deposited On: | 18 Aug 2011 07:32 |
| Last Modified: | 18 Aug 2011 07:32 |
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