Reddy, Venky Sreedhar ; Venkata Rao, D. K. ; Rajasekharan, Ram (2010) Functional characterization of lysophosphatidic acid phosphatase from Arabidopsis thaliana Biochimica et Biophysica Acta (BBA) - Molecular and Cell Biology of Lipids, 1801 (4). pp. 455-461. ISSN 1388-1981
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Official URL: http://www.sciencedirect.com/science/article/pii/S...
Related URL: http://dx.doi.org/10.1016/j.bbalip.2009.12.005
Abstract
Lysophosphatidic acid (LPA) acts as a signaling molecule that regulates diverse cellular processes and it can rapidly be metabolized by phosphatase and acyltransferase. LPA phosphatase gene has not been identified and characterized in plants so far. The BLAST search revealed that the At3g03520 is similar to phospholipase family, and distantly related to bacterial phosphatases. The conserved motif, (J)4XXXNXSFD, was identified in both At3g03520 like phospholipases and acid phosphatases. In silico expression analysis of At3g03520 revealed a high expression during phosphate starvation and abiotic stresses. This gene was overexpressed in Escherichia coli and shown to posses LPA specific phosphatase activity. These results suggest that this gene possibly plays a role in signal transduction and storage lipid synthesis.
| Item Type: | Article |
|---|---|
| Source: | Copyright of this article belongs to Elsevier Science. |
| Keywords: | Lysophosphatidic Acid Phosphatase; Lipid Metabolism; Phylogenetic Analysis; Soluble Triacylglycerol Biosynthesis; Phospholipases; Conserved Motif |
| ID Code: | 55031 |
| Deposited On: | 17 Aug 2011 12:22 |
| Last Modified: | 17 Aug 2011 12:22 |
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