Nagar, S. ; Juyal, R. C. ; Chaudhary, S. ; Behari, M. ; Gupta, M. ; Rao, S. N. ; Thelma, B. K. (2001) Mutations in the α-synuclein gene in Parkinson's disease among Indians Acta Neurologica Scandinavica, 103 (2). pp. 120-122. ISSN 0001-6314
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Official URL: http://onlinelibrary.wiley.com/doi/10.1034/j.1600-...
Related URL: http://dx.doi.org/10.1034/j.1600-0404.2001.103002120.x
Abstract
Objective: To investigate the prevalence of G88C, G209A and any other mutation(s) in exons 3 and 4 of theα-synuclein gene in Indian patients with Parkinson's disease (PD). Methods: A total of 169 PD patients comprising 18 familial, 3 juvenile, 48 early onset and 100 sporadic cases were included in this study. Genomic DNA was amplified by PCR using primers specific for Exons 3 and 4. Mutations at G88C and G209A were screened following restriction enzyme digestion of the PCR product. Direct PCR product sequencing of entire exons 3 and 4 was carried out for at least one proband each from the 10 familial cases. Results: Neither G88C and G209A mutations nor any other mutation in exons 3 and 4 was found in the PD patients analysed. Conclusion: The G88C and G209A mutations do not seem to be the predominant genetic determinant of PD among Indians.
| Item Type: | Article |
|---|---|
| Source: | Copyright of this article belongs to John Wiley and Sons. |
| Keywords: | Parkinson's Disease; α-synuclein Gene; G209a Mutation; G88c Mutation; Indian Population |
| ID Code: | 54644 |
| Deposited On: | 12 Aug 2011 06:52 |
| Last Modified: | 12 Aug 2011 06:52 |
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