Tiwari, Arun K. ; Deshpande, Smita N. ; Rao, A. R. ; Bhatia, Triptish ; Lerer, Bernard ; Nimgaonkar, Vishwajit L. ; Thelma, B. K. (2005) Genetic susceptibility to tardive dyskinesia in chronic schizophrenia subjects: III. Lack of association of CYP3A4 and CYP2D6 gene polymorphisms Schizophrenia Research, 75 (1). pp. 21-26. ISSN 0920-9964
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Official URL: http://www.sciencedirect.com/science/article/pii/S...
Related URL: http://dx.doi.org/10.1016/j.schres.2004.12.011
Abstract
Tardive dyskinesia is a severe debilitating movement disorder characterized by choreoathetotic movements developing in one-fifth of the patients with schizophrenia. In this study we have investigated the significance of CYP3A4*1B and CYP2D6*4 polymorphisms in TD susceptibility among chronic schizophrenia patients (n=335) from north India. Tardive dyskinesia was diagnosed in ~29% (96/335) of these patients. No significant association of either of the two SNPs with TD (CYP3A4*1B χ2=0. 308, df=1, p=0.579; CYP2D64χ 2=0.006, df=1, p=0.935) was observed. However a trend towards increased severity of TD in patients heterozygous for the CYP2D64 mutation was observed.
| Item Type: | Article |
|---|---|
| Source: | Copyright of this article belongs to Elsevier Science. |
| Keywords: | Tardive Dyskinesia; Single Nucleotide Polymorphism; Association; CYP2D6; CYP3A4; Pharmacogenetics |
| ID Code: | 54639 |
| Deposited On: | 12 Aug 2011 06:54 |
| Last Modified: | 12 Aug 2011 06:54 |
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