Initial loss of secondary structure in the unfolding of barstar

Nath, Utpal ; Agashe, Vishwas R. ; Udgaonkar, Jayant B. (1996) Initial loss of secondary structure in the unfolding of barstar Nature Structural and Molecular Biology, 3 (11). pp. 920-923. ISSN 1072-8368

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Official URL: http://www.nature.com/nsmb/journal/v3/n11/abs/nsb1...

Related URL: http://dx.doi.org/10.1038/nsb1196-920

Abstract

Rapid (millisecond) far-UV circular dichroism and fluorescence-monitored kinetic studies of the unfolding of barstar demonstrate the accumulation of a compact intermediate devoid of much secondary structure, before the rate limiting step in unfolding.

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