Patra, D. ; Srikalaivani, R. ; Misra, A. ; Singh, D. D. ; Selvaraj, M. ; Vijayan, M. (2010) Cloning, expression, purification, crystallization and preliminary X-ray studies of a secreted lectin (Rv1419) from Mycobacterium tuberculosis Acta Crystallographica Section F, 66 . pp. 1662-1665. ISSN 1744-3091
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Official URL: http://scripts.iucr.org/cgi-bin/paper?bw5375
Related URL: http://dx.doi.org/10.1107/S1744309110042892
Abstract
A secreted lectin, Rv1419, from Mycobacterium tuberculosis has been cloned, expressed, purified and crystallized and the crystals have been characterized. This represents the first X-ray investigation of a lectin or lectin-like molecule from the pathogen. The cubic crystals contain one molecule in the asymmetric unit. Sequence comparisons indicate that the lectin has a β-trefoil fold and belongs to a well characterized family of carbohydrate-binding modules. Structural analysis of the crystals is in progress.
| Item Type: | Article |
|---|---|
| Source: | Copyright of this article belongs to International Union of Crystallography. |
| Keywords: | Bacterial Lectins; Mycobacterium tuberculosis; β-trefoil Fold; Sugar Binding |
| ID Code: | 53860 |
| Deposited On: | 10 Aug 2011 09:39 |
| Last Modified: | 10 Aug 2011 09:39 |
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