Tosh, Kerrie ; Meisner, Sarah ; Ruby Siddiqui, M. ; Balakrishnan, Karuppiah ; Ghei, Satish ; Golding, Marina ; Sengupta, Utpal ; Pitchappan, Ramasamy M. ; Hill, Adrian V. S. (2002) A region of chromosome 20 is linked to leprosy susceptibility in a South Indian population The Journal of Infectious Diseases, 186 (8). pp. 1190-1193. ISSN 0022-1899
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Official URL: http://jid.oxfordjournals.org/content/186/8/1190.s...
Related URL: http://dx.doi.org/10.1086/343806
Abstract
A major susceptibility locus for leprosy has recently been mapped on chromosome 10 (10p13) by genome-wide linkage analysis. Microsatellite markers from this genome screen that showed suggestive evidence of linkage to leprosy were evaluated in an additional 140 families with affected sib pairs. A second region of linkage has thus been identified on chromosome 20 (20p12). The peak of linkage lies at marker D20S115 which has a significant single-point maximum logarithm of odds score of 3.48 (P=.00003). Transmission disequilibrium testing of the microsatellite markers in 20p12 showed that the marker D20S835 is associated with protection against leprosy (P=.021), which suggests that a locus controlling susceptibility lies close to this marker.
| Item Type: | Article |
|---|---|
| Source: | Copyright of this article belongs to University of Chicago Press. |
| ID Code: | 53383 |
| Deposited On: | 08 Aug 2011 12:22 |
| Last Modified: | 08 Aug 2011 12:22 |
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