Shanmugam, G. (1976) Endonucleolytic cleavage of murine leukemia virus 35S RNA by microsome-associated nuclease Biochemical and Biophysical Research Communications, 70 (3). pp. 818-823. ISSN 0006-291X
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Official URL: http://www.sciencedirect.com/science/article/pii/0...
Related URL: http://dx.doi.org/10.1016/0006-291X(76)90665-3
Abstract
Moloney murine leukemia virus 35S RNA (molecular weight 3 to 3.4 × 106) is cleaved by nuclease activity present in microsomal fractions from MLV infected or uninfected mouse embryo cells to two RNA species of approximate molecular weights 1.8 × 106 and 1.5 × 106. Microsomal fractions from MLV infected and uninfected cells also contained nucleolytic activity that solubilized [3H]poly(A)·poly(U) but not [3H]poly(C) or [3H]poly(U); the cleavage of poly(A)·poly(U) was inhibited by ethidium bromide. The cleavage of MLV RNA was also inhibited by ethidium bromide, suggesting double stranded regions in 35S RNA as the site of cleavage.
| Item Type: | Article |
|---|---|
| Source: | Copyright of this article belongs to Elsevier Science. |
| Keywords: | MLV; Murine Leukemia Virus; HPME; High Passage Swiss Mouse Embryo |
| ID Code: | 52799 |
| Deposited On: | 04 Aug 2011 08:09 |
| Last Modified: | 04 Aug 2011 08:09 |
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