Tuteja, Narendra ; Huang, Ning Wu ; Skopac, Doris ; Tuteja, Renu ; Hrvatic, Sara ; Zhang, Jianwen ; Pongor, Sandor ; Joseph, Gérard ; Faucher, Christian ; Amalric, François ; Falaschi, Arturo (1995) Human DNA helicase IV is nucleolin, an RNA helicase modulated by phosphorylation Gene, 160 (2). pp. 143-148. ISSN 0378-1119
Full text not available from this repository.
Official URL: http://www.sciencedirect.com/science/article/pii/0...
Related URL: http://dx.doi.org/10.1016/0378-1119(95)00207-M
Abstract
The cDNA encoding human DNA helicase IV (HDH IV), a 100-kDa protein which unwinds DNA in the 5' to 3' direction with respect to the bound strand, was cloned and sequenced. It was found to be identical to the human cDNA encoding nucleolin, a ubiquitous eukaryotic protein essential for pre-ribosome assembly. HDH IV/nucleolin can unwind RNA-RNA duplexes, as well as DNA-DNA and DNA-RNA duplexes. Phosphorylation of HDH IV/nucleolin by cdc2 kinase and casein kinase II enhanced its unwinding activity in an additive way. The Gly-rich C-terminal domain possesses a limited ATP-dependent duplex-unwinding activity which contributes to the helicase activity of HDH IV/nucleolin.
| Item Type: | Article |
|---|---|
| Source: | Copyright of this article belongs to Elsevier Science. |
| Keywords: | Unwinding Enzyme; cdc2; Casein Kinase; Nucleolus; Pre-ribosome Assembly |
| ID Code: | 52584 |
| Deposited On: | 04 Aug 2011 11:57 |
| Last Modified: | 04 Aug 2011 11:57 |
Repository Staff Only: item control page
