Intimate nature of muscular contraction

Abstract

It was originally proposed by Astbury that muscular contraction was due to coiling or folding of the contractile proteins. A model of the structure of muscle sarcomere was recently proposed by A. F. Huxley and Neidergerke and by H. E. Huxley and Hanson; their model shows that filaments of action and myosin slide past each other during contraction. A. F. Huxley proposed a hypothesis of contraction in which it is assumed that active shortening or the development of tension is brought about by generation of relative translational forces between actin and myosin filaments at a series of points in the region of overlap.