Madhusudanan, K. P. ; Chattopadhyay, S. K. ; Saha, G. C. ; Kulshrestha, M. ; Sharma, R. P. ; Sushil Kumar, (1997) Fast atom bombardment mass spectrometry for the characterization of taxanes Journal of Mass Spectrometry, 32 (2). pp. 216-224. ISSN 1076-5174
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Official URL: http://onlinelibrary.wiley.com/doi/10.1002/(SICI)1...
Related URL: http://dx.doi.org/10.1002/(SICI)1096-9888(199702)32:2<216::AID-JMS473>3.0.CO;2-S
Abstract
Fast atom bombardment mass spectrometry (FABMS) of several taxanes and 11(15→1)abeo-taxanes having a 4(20)-exocyclic methylene group or oxetane ring was studied in detail using collision-induced dissociation (CID) of their [M+Li]+, [M+Na]+ and [M+NH4]+ ions. The results indicate that FAB followed by MS/MS is a valuable tool for the identification of functional groups in taxanes and to some extent the type of taxane under investigation. The presence of hydroxy groups in the molecule is best confirmed by examining the CID of the [M+NH4]+ adduct ions. The 11(15→1)abeo-taxanes are characterized by elimination of the hydroxyisopropylidene group with an acetoxy or benzoyloxy group.
| Item Type: | Article |
|---|---|
| Source: | Copyright of this article belongs to John Wiley and Sons. |
| Keywords: | Fast Atom Bombardment Mass Spectrometry; Collision-induced Dissociation; Taxanes Cationization |
| ID Code: | 52157 |
| Deposited On: | 02 Aug 2011 07:46 |
| Last Modified: | 02 Aug 2011 07:46 |
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