Sushil Kumar, ; Aggarwal, Urmila ; Swaminathan, M. S. (1967) Chromosome breakage induced in Vicia faba by a monofunctional alkylating derivative of acridine Mutation Research: Fundamental and Molecular Mechanisms of Mutagenesis, 4 (2). pp. 155-132. ISSN 1386-1964
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Official URL: http://www.sciencedirect.com/science/article/pii/0...
Related URL: http://dx.doi.org/10.1016/0027-5107(67)90067-X
Abstract
1. (1) The chromosome-breaking ability of the monofunctional nitrogen mustard derivative of acridine, 2-methoxy-6-chloro-9-[3-(ethyl-2-chloroethyl) aminopropylamine]acridine dihydrochloride (ICR-170), on chromosomes of Vicia faba has been demonstrated. 2. (2) It is concluded that chromatid-type aberrations are induced in cells in G1, S and G2 and subchromatid type of aberrations in cells in prophase in the first mitosis (T1) after treatment, and that chromosome-type aberrations recovered after ICR-170 treatment are not from G1 cells of T1 mitosis but are products in T2 mitosis of duplication of chromatid-type aberrations of T1 mitosis. 3. (3) The action of the monofunctional alkylating component of the ICR-170 molecule seems to play a predominant role in aberration induction.
| Item Type: | Article |
|---|---|
| Source: | Copyright of this article belongs to Elsevier Science. |
| ID Code: | 52092 |
| Deposited On: | 02 Aug 2011 07:39 |
| Last Modified: | 04 Jul 2012 08:43 |
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