Srikrishna, A. ; Satyanarayana, G. ; Desai, Uday V. (2007) Efficient approach to 4-benzyl-5,5-dimethyldihydrofuranones: total synthesis of (±_bold;)-solafuranone Synthetic Communications, 37 (6). pp. 965-976. ISSN 0039-7911
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Official URL: http://www.tandfonline.com/doi/abs/10.1080/0039791...
Related URL: http://dx.doi.org/10.1080/00397910601163919
Abstract
A six-step general and very efficient synthesis of 4-(arylmethyl)-5,5-dialkyldihydrofuranones starting from corresponding aryl aldehyde has been developed. Solafuranone, a novel furanone isolated from the Chinese folk medicine Solanum indicum, has been accomplished starting from 2,6-dimethylbenzaldehyde in six steps in an overall yield of 70%. Contrary to expectations, solafuranone and its analogue failed to exhibit any significant cytotoxicity against A549 (lung adenocarcinoma) and HL60 (leukemia cells) cell lines.
| Item Type: | Article |
|---|---|
| Source: | Copyright of this article belongs to Taylor and Francis Group. |
| Keywords: | Cytotoxicity; Dihydrofuranone; Lycifuranones A and B; Solafuranone; Solanum indicum |
| ID Code: | 51558 |
| Deposited On: | 28 Jul 2011 14:33 |
| Last Modified: | 28 Jul 2011 14:33 |
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