Wootla, Bharath ; Mahendra, Ankit ; Dimitrov, Jordan D. ; Friboulet, Alain ; Borel-Derlon, Annie ; Rao, Desirazu N. ; Uda, Taizo ; Borg, Jeanne-Yvonne ; Bayry, Jagadeesh ; Kaveri, Srinivas V. ; Lacroix-Desmazes, Sébastien (2009) Factor VIII-hydrolyzing IgG in acquired and congenital hemophilia FEBS Letters, 583 (15). pp. 2565-2572. ISSN 0014-5793
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Official URL: http://linkinghub.elsevier.com/retrieve/pii/s0014-...
Related URL: http://dx.doi.org/10.1016/j.febslet.2009.07.009
Abstract
Anti-factor VIII (FVIII) inhibitory IgG may arise as alloantibodies to therapeutic FVIII in patients with congenital hemophilia A, or as autoantibodies to endogenous FVIII in individuals with acquired hemophilia. We have described FVIII-hydrolyzing IgG both in hemophilia A patients with anti-FVIII IgG and in acquired hemophilia patients. Here, we compared the properties of proteolytic auto- and allo-antibodies. Rates of FVIII hydrolysis differed significantly between the two groups of antibodies. Proline-phenylalanine-arginine-methylcoumarinamide was a surrogate substrate for FVIII-hydrolyzing autoantibodies. Our data suggest that populations of proteolytic anti-FVIII IgG in acquired hemophilia patients are different from that of inhibitor-positive hemophilia A patients.
| Item Type: | Article |
|---|---|
| Source: | Copyright of this article belongs to Elsevier Science. |
| Keywords: | Catalytic Antibody; Acquired Hemophilia; Hemophilia A; FVIII Inhibitor; Factor VIII; PFR-MCA |
| ID Code: | 51225 |
| Deposited On: | 28 Jul 2011 07:27 |
| Last Modified: | 28 Jul 2011 07:27 |
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