Singh, Manmohan ; Singh, Om ; Singh, Amarjit ; Talwar, G. P. (1992) Immunogenicity studies on diphtheria toxoid loaded biodegradable microspheres International Journal of Pharmaceutics, 85 (1-3). R5-R8. ISSN 0378-5173
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Official URL: http://www.sciencedirect.com/science/article/pii/0...
Related URL: http://dx.doi.org/10.1016/0378-5173(92)90157-W
Abstract
Diphtheria toxoid loaded polylactide microspheres were prepared using the solvent evaporation method. The vaccine loaded microspheres were subjected to in vitro antigen release studies and in vivo immune response tests. The immunogenicity of the vaccine after microencapsulation was compared to that against diphtheria toxoid given in the conventional three injection schedule on alum as an adjuvant. The antibody response seen in the two cases is compared. The duration of the immune response from the two schedules is exhibited.
| Item Type: | Article |
|---|---|
| Source: | Copyright of this article belongs to Elsevier Science. |
| Keywords: | Vaccine Delivery; Immune Response; Antibody Titer; Polymer Erosion; ELISA |
| ID Code: | 50663 |
| Deposited On: | 26 Jul 2011 08:18 |
| Last Modified: | 26 Jul 2011 08:18 |
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