Metabolic, endocrine and organ functions in monkeys immunized with Pr-β-HCG-TT vaccine

Abstract

A number of blood and urine constituents have been analysed in 12 rhesus monkeys immunized with Pr-β-HCG-TT vaccine for periods ranging up to 13 months and in 10 nonimmunized controls. These include serum bilirubin, alkaline phosphatase, glutamic oxaloacetic and glutamic pyruvic transaminases, true and pseudo cholinesterases, lactic acid dehydrogenase and its isozymes, blood glucose, cholesterol, free fatty acids, serum proteins, plasma cortisol, serum creatinine, blood urea, hemoglobin, total and differential counts of blood cells and packed cell volume. Physical, chemical and microscopic analysis of the urine was also carried out. The data show that except for the clinically insignificant variation in the proportion of lymphocytes and neutrophils and in serum transaminases, all the components analysed were comparable in the two groups and no differences were observable in the immunized and non-immunized monkeys.