Influence of HCG and tetanus toxoid injections on the antibody titers in a subject immunized with Pr-β-HCG-TT

Abstract

N.D., a subject immunized 11 months earlier with Pr-β-HCG-TT in whom the anti-HCG titers were on the decline, was injected with 2,000 IU and 4,000 IU of HCG intramuscularly at 24-hour intervals. The anti-HCG titers in blood fell in response to HCG administration but remained above zero. No evidence for the presence of free HCG was found in circulation. HCG administration did not alter the anti-tetanus toxoid titers. The anti-HCG titers in the blood sample drawn 21 days after the load test showed a return to nearly about the initial values. No clear cut booster effect of HCG injection on anti-HCG titers was noted. On the other hand injection of tetanus toxoid vaccine increased the antitetanus toxoid antibodies in the subject.