Efficacy of antibodies generated by PR-β-hCG-TT to terminate pregnancy in baboons: its reversibility and rescue by medroxyprogesterone acetate

Tandon, A. ; Das, C. ; Jailkhani, B. L. ; Talwar, G. P. (1981) Efficacy of antibodies generated by PR-β-hCG-TT to terminate pregnancy in baboons: its reversibility and rescue by medroxyprogesterone acetate Contraception, 24 (1). pp. 83-95. ISSN 0010-7824

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Official URL: http://www.contraceptionjournal.org/article/0010-7...

Related URL: http://dx.doi.org/10.1016/0010-7824(81)90071-8

Abstract

Antibodies produced by the vaccine Pr-β-hCG-TT in monkeys were effective in terminating pregnancy in baboons on passive administration. The animals returned to cyclicity soon after the onset of vaginal bleeding. Fertility was regained. Globulins from non-immunized control monkeys in amounts, volume and injection schedule similar to those employed for passive termination did not intercept pregnancy. The abortifacient action of anti-CG antibodies could be counteracted by administration of medroxyprogesterone acetate.

Item Type:Article
Source:Copyright of this article belongs to Elsevier Science.
ID Code:50644
Deposited On:26 Jul 2011 08:05
Last Modified:26 Jul 2011 08:05

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