Iyer, K. S. N. ; Sahal, D. ; Talwar, G. P. (1986) Chemical synthesis and immunological properties of a cyclic eicosapeptide (Gly88,90) 82-101 of the beta subunit of human chorionic gonadotrophin International Journal of Peptide and Protein Research, 27 (6). pp. 604-612. ISSN 0367-8377
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Official URL: http://onlinelibrary.wiley.com/doi/10.1111/j.1399-...
Related URL: http://dx.doi.org/10.1111/j.1399-3011.1986.tb01056.x
Abstract
The eicosapeptide (Gly88,90) 82-101 hCG-β was synthesized by the fragment condensation of the nonapeptide (Gly88,90) 82-90 and the undecapeptide 91-101 followed by iodine oxidation to make the disulfide loop. Intramolecularity of the disulfide linking cysteines at 93 and 100 was confirmed. Anti-peptide antibodies were elicited in rabbits upon immunization with a conjugate of the peptide with tetanus toxoid. The repertoire of these antibodies was directed solely against the undecapeptide 91-101. These antibodies showed no recognition for hCG, hCG-β or ARCM hCG-β, suggesting that the conformational epitopes of hCG-β in the region 82-101 may not be accessible to antibodies.
| Item Type: | Article |
|---|---|
| Source: | Copyright of this article belongs to Munksgaard International Publishers. |
| Keywords: | Peptide Synthesis; Immunogenicity of Peptides; Intramolecular Disulfide; Synthetic Vaccine |
| ID Code: | 50543 |
| Deposited On: | 26 Jul 2011 08:09 |
| Last Modified: | 26 Jul 2011 08:09 |
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