The P domain of the P0 protein of Plasmodium falciparum protects against challenge with malaria parasites

Rajeshwari, K. ; Patel, Kalpesh ; Nambeesan, Savithri ; Mehta, Monika ; Sehgal, Alfica ; Chakraborty, Tirtha ; Sharma, Shobhona (2004) The P domain of the P0 protein of Plasmodium falciparum protects against challenge with malaria parasites Infection and Immunity, 72 (9). pp. 5515-5521. ISSN 0019-9567

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Official URL: http://iai.asm.org/cgi/content/abstract/72/9/5515

Related URL: http://dx.doi.org/10.1128/IAI.72.9.5515-5521.2004

Abstract

Monoclonal antibodies (MAbs) specific for the P domain of the Plasmodium falciparum P0 phosphoriboprotein (PfP0) blocked the invasion of RBCs by P. falciparum. Vaccination with this P-domain peptide protected mice upon malaria parasite challenge. The absolute specificity of the MAbs and the PfP0 P peptide makes them potential protective malaria reagents.

Item Type:Article
Source:Copyright of this article belongs to American Society for Microbiology.
ID Code:50346
Deposited On:23 Jul 2011 08:30
Last Modified:18 May 2016 04:41

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