Maiti, M. ; Rao, M. ; Sastry, S. (2010) Competition between folding and aggregation in a model for protein solutions The European Physical Journal E: Soft Matter and Biological Physics, 32 (2). pp. 217-221. ISSN 1292-8941
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Official URL: http://www.springerlink.com/content/331073h620632k...
Related URL: http://dx.doi.org/10.1140/epje/i2010-10621-4
Abstract
We study the thermodynamic and kinetic consequences of the competition between single-protein folding and protein-protein aggregation using a phenomenological model, in which the proteins can be in the unfolded (U), misfolded (M) or folded (F) states. The phase diagram shows the coexistence between a phase with aggregates of misfolded proteins and a phase of isolated proteins (U or F) in solution. The spinodal at low protein concentrations shows non-monotonic behavior with temperature, with implications for the stability of solutions of folded proteins at low temperatures. We follow the dynamics upon "quenching" from the U-phase (cooling) or the F-phase (heating) to the metastable or unstable part of the phase diagram that results in aggregation. We describe how interesting consequences to the distribution of aggregate size, and growth kinetics arise from the competition between folding and aggregation.
Item Type: | Article |
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Source: | Copyright of this article belongs to Springer. |
ID Code: | 50183 |
Deposited On: | 21 Jul 2011 14:50 |
Last Modified: | 21 Jul 2011 14:50 |
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