Block, L. H. ; Georgopoulos, A. ; Biemesderfer, D. ; Herzog, C. ; Kashgarian, M. ; Sitaramam, V. (1986) Ubiquinone-8 stimulates phagocytosis in macrophages by modulation of the kinetics of the Fc receptor The Journal of Infectious Diseases, 153 (2). pp. 209-215. ISSN 0022-1899
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Official URL: http://jid.oxfordjournals.org/content/153/2/209.sh...
Related URL: http://dx.doi.org/10.1093/infdis/153.2.209
Abstract
The effect of exogenous ubiquinone-8 (Q8) on IgG-and C3b-mediated phagocytosis of sensitized sheep red blood cells and of opsonized Staphylococcus aureus by macrophages was studied by morphological and quantitative methods. Q8 stimulated the initial events of phagocytosis, that is, attachment and ingestion, in which occupancy of the Fe receptor by IgG was shown to be of critical significance. The kinetics of competitive inhibition of phagocytosis of opsonized bacteria by macrophages by using Fe fragments suggested the intimate role of the kinetics of the Fe receptor in the initial events of phagocytosis and, further, the modulation of the kinetics of the Fe receptor by Q8 as the basis of enhanced phagocytosis by Q8.
| Item Type: | Article |
|---|---|
| Source: | Copyright of this article belongs to University of Chicago Press. |
| ID Code: | 49833 |
| Deposited On: | 21 Jul 2011 10:03 |
| Last Modified: | 21 Jul 2011 10:03 |
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