Anomalous permeability and stability characteristics of erythrocytes in non-electrolyte media

Sambasivarao, D. ; Rao, N. M. ; Sitaramam, V. (1986) Anomalous permeability and stability characteristics of erythrocytes in non-electrolyte media Biochimica et Biophysica Acta (BBA) - Biomembranes, 857 (1). pp. 48-60. ISSN 0005-2736

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Official URL: http://www.sciencedirect.com/science/article/pii/0...

Related URL: http://dx.doi.org/10.1016/0005-2736(86)90097-0

Abstract

The permeability characteristics of the erythrocyte membrane were critically evaluated in electrolyte and non-electrolyte (sucrose) media by ion-selective electrodes and radioactive polyol fluxes as well as by the novel technique of osmometry. K+ efflux demonstrated a linear osmotic susceptibility distinct from Na+ influx upon incubation in NaCl media of various tonicities. In non-electrolyte media, acidification of the medium, large fluxes of K+, sucrose and even haemoglobin (as manifest by hypertonic disruption) were consistent with enhanced porosity of the bilayer due to the field created by surface charge density leading to density fluctuations in the bilayer.

Item Type:Article
Source:Copyright of this article belongs to Elsevier Science.
Keywords:Hypertonic Disruption; Osmolysis; Membrane Surface Charge; Ionic Detergent; (Rat Erythrocyte)
ID Code:49811
Deposited On:21 Jul 2011 10:04
Last Modified:21 Jul 2011 10:04

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