Prabhu, N. S. ; Somasundaram, K. ; Satyamoorthy, K. ; Herlyn, M. ; El-Deiry, W. S. (1998) p73Beta, unlike p53, suppresses growth and induces apoptosis of human papillomavirus E6-expressing cancer cells International Journal of Oncology, 13 (1). pp. 3-9. ISSN 1019-6439
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Official URL: http://www.spandidos-publications.com/ijo/13/1/5
Abstract
Human papillomavirus (HPV) is the major cause of cervical cancer worldwide. HPV-E6 protein targets the p53 tumor suppressor protein for degradation by ubiquitin-mediated proteolysis making such cancers resistant to p53-gene therapy. Here we show that infection of human cancer cells by E6-expressing adenovirus (Ad-E6) leads to degradation of both wild-type or mutant p53 protein. Interestingly, the p53-homologue candidate tumor suppressor p73 is not degraded in Ad-E6 infected cancer cells. Wild-type p73beta and not wild-type p53 or mutant p73 is a potent inhibitor of cancer colony growth and inducer of apoptosis, despite HPV-E6 overexpression. The results suggest a novel strategy using p73beta in gene therapy of HPV-E6 expressing cancers.
Item Type: | Article |
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Source: | Copyright of this article belongs to Spandidos Publications Ltd. |
ID Code: | 49716 |
Deposited On: | 20 Jul 2011 13:51 |
Last Modified: | 20 Jul 2011 13:51 |
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