Interaction of non-intercalative drugs with DNA: distamycin analogues

Rajagopalan, Malini ; Ayyer, Jayalekshmy ; Sasisekharan, V. (1985) Interaction of non-intercalative drugs with DNA: distamycin analogues Journal of Biosciences, 7 (1). pp. 27-32. ISSN 0250-5991

[img]
Preview
PDF - Publisher Version
295kB

Official URL: http://www.ias.ac.in/jarch/jbiosci/7/27-32.pdf

Related URL: http://dx.doi.org/10.1007/BF02716763

Abstract

Distamycin and netropsin are two oligopeptides which bind to DNA in a nonintercalative manner. Analogues of distamycin have been synthesized and their binding with poly d(A-T) studied using ultraviolet absorption spectroscopy. Preliminary biological activity tests on a gram positive bacteria using these analogues have also been carried out.

Item Type:Article
Source:Copyright of this article belongs to Indian Academy of Sciences.
Keywords:Non-intercalative Binding; DNA; Distamycin Analogues
ID Code:49595
Deposited On:20 Jul 2011 14:24
Last Modified:18 May 2016 04:15

Repository Staff Only: item control page