Parrack, Pradipkumar ; Dasgupta, Dipak ; Ayyer, Jayalekshmy ; Sasisekharan, V. (1987) Interaction of synthetic analogs of distamycin with DNA: Role of the conjugated N-methylpyrrole system in specificity of binding FEBS Letters, 212 (2). pp. 297-301. ISSN 0014-5793
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Official URL: http://www.sciencedirect.com/science/article/pii/0...
Related URL: http://dx.doi.org/10.1016/0014-5793(87)81364-9
Abstract
Interaction of two synthetic analogs of distamycin (Dst), PPA and PAP, containing a saturated β-alanine moiety replacing one N-methylpyrrole ring, with different polynucleotides and natural DNAs were studied using UV and CD spectroscopy. The results indicate that, similar to Dst, these analogs bind to DNA via the minor groove with a specificity towards AT-base pairs. It may be proposed that pyrrole chromophores in Dst probably do not play a role in the AT-base selectivity exhibited by Dst.
| Item Type: | Article |
|---|---|
| Source: | Copyright of this article belongs to Elsevier Science. |
| Keywords: | Drug-DNA Interaction; Distamycin Analog; AT-base Specificity; Minor Groove Binding |
| ID Code: | 49574 |
| Deposited On: | 21 Jul 2011 10:32 |
| Last Modified: | 21 Jul 2011 10:32 |
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