Lal, Girdhari ; Shaila, M. S. ; Nayak, Rabindranath (2006) Booster immunization of antigen primed mice with anti-idiotypic T cells generates antigen-specific memory T cell response Vaccine, 24 (8). pp. 1149-1158. ISSN 0264-410X
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Official URL: http://www.sciencedirect.com/science/article/pii/S...
Related URL: http://dx.doi.org/10.1016/j.vaccine.2005.08.099
Abstract
Immunological memory is characterized by quick and enhanced immune response after re-exposure to the same antigen. In the present work, we have shown that anti-idiotypic T cells are generated in mice after immunization with idiotypic T cell clone or polyclonal T cell specific for nucleocapsid protein of Rinderpest virus. Further, we have shown that N specific idiotypic T cell receptors from apoptotic idiotypic T cells are processed by bone marrow derived dendritic cells and presented to cognate anti-idiotypic T cells. Evidence has been provided for the existence of antigen specific T cell idiotypic network in the body. Boosting with antigen specific anti-idiotypic T cells generates memory response in the antigen-primed mice.
| Item Type: | Article |
|---|---|
| Source: | Copyright of this article belongs to Elsevier Science. |
| Keywords: | T Cell Memory; Anti-idiotypic T Cells; Idiopeptide; Peptidomimics; Relay Hypothesis |
| ID Code: | 49293 |
| Deposited On: | 19 Jul 2011 13:59 |
| Last Modified: | 19 Jul 2011 14:44 |
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