Sriprakash, K. S. ; Ramakrishnan, T. (1970) Isoniazid-resistant mutants of Mycobacterium tuberculosis H 37 RV: uptake of isoniazid and the properties of NADase inhibitor Microbiology, 60 (1). pp. 125-132. ISSN 1350-0872
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Official URL: http://mic.sgmjournals.org/cgi/content/abstract/60...
Related URL: http://dx.doi.org/10.1099/00221287-60-1-125
Abstract
Six independent isoniazid-resistant mutants of Mycobacterium tuberculosis were isolated under conditions which largely ensured the selection of one-step mutants. The properties of these mutants with respect to the nicotinamide adenine dinucleotide nucleosidase (NADase) inhibitor, isoniazid uptake and peroxidase activity were studied. The uptake of isoniazid by the mutants and their sensitivity to isoniazid were increased by ethylenediaminetetra-acetic acid (EDTA) and sodium dodecylsulphate. It is suggested that EDTA and sodium dodecylsulphate bring about these effects by altering the cell permeability.
Item Type: | Article |
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Source: | Copyright of this article belongs to Society for General Microbiology. |
ID Code: | 49213 |
Deposited On: | 19 Jul 2011 11:45 |
Last Modified: | 18 May 2016 04:01 |
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