Cryptands and related tripodal ligands: interaction with nucleic acids and nuclease activity of their Eu(III) complexes

Chand, Dillip Kumar ; Bharadwaj, Parimal K. ; Schneider, Hans-Jorg (2001) Cryptands and related tripodal ligands: interaction with nucleic acids and nuclease activity of their Eu(III) complexes Tetrahedron, 57 (31). pp. 6727-6732. ISSN 0040-4020

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Official URL: http://linkinghub.elsevier.com/retrieve/pii/S00404...

Related URL: http://dx.doi.org/10.1016/S0040-4020(01)00630-5

Abstract

Three tripodal ligands (1-3), three macrobicyclic cryptands (4-5), the [222] and [221] cryptands 7 and 8, and corresponding Eu(III) complexes were probed for their influence on double-stranded nucleic acids. One ligand (2) shows higher affinity to DNA as compared to RNA and another one (4) even slightly destabilizes RNA. Cryptands 7 and 8 show no detectable melting point effects; addition of the [222] cryptand 7 to Eu(III) salts has no significant effect on the nuclease activity of the free metal ion. Only the [221] cryptand 8 forms a stable complex with Eu(III) in water, leading to almost no rate decrease with the phosphodiester BNPP, in striking contrast to DNA. The histidine-containing ligand 2 exhibits an increased hydrolytic activity against BNPP and against plasmid DNA.

Item Type:Article
Source:Copyright of this article belongs to Elsevier Science.
Keywords:Polyamines; Cryptands; Europium Complexes; DNA/RNA Affinities; Phosphorester Cleavage; Catalysis
ID Code:4890
Deposited On:18 Oct 2010 06:19
Last Modified:18 May 2011 08:33

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