The crafting of uracils with enhanced stacking potential

Abstract

Uracils having enhanced stacking profile are of interest from diverse vantages ranging from the chemical simulation of transcription to the design of novel anti viral agents. This objective has been realized by synthetic strategies leading to uracils having,inter alia, pseudo aromatic and hydrophobic rings crafted to the 5-6 location and ionophore and hydrophobic chains affixed at the C-5 and nitrogen atoms. Endeavours to prepare a 5-2' uracil-pyrimidine composite have led to novel uracil arising from 2-O → =CH(COOR)₂ transformation and a tethered malonic acid pyrimidine complex.