Sharma, Yagya D. ; Kilejian, Araxie (1987) Structure of the knob protein (KP) gene of Plasmodium falciparum Molecular and Biochemical Parasitology, 26 (1-2). pp. 11-16. ISSN 0166-6851
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Official URL: http://www.sciencedirect.com/science/article/pii/0...
Related URL: http://dx.doi.org/10.1016/0166-6851(87)90124-1
Abstract
We have determined the nucleotide sequence of the gene encoding the knob protein (KP) of Plasmodium falciparum (FCR-3/Gambia). The gene is interrupted by an intron which contains 34 imperfect tandemly repeated ATTTT sequences. The first exon encodes 33 amino acids with a hydrophobic core typical of signal peptides. The second exon has an open translational reading frame for 597 amino acids. The deduced protein sequence indicates that KP has multiple structural domains; unlike the N-terminal histidine-rich domain which we described previously, the C-terminal half is rich in lysine residues. Consistent with the apparent association of KP with the cytoplasmic surface of the host erythrocyte membrane, the protein is highly charged and hydrophilic.
Item Type: | Article |
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Source: | Copyright of this article belongs to Elsevier Science. |
Keywords: | Plasmodium falciparum; Knob Protein; Malaria; Histidine-rich Protein |
ID Code: | 48648 |
Deposited On: | 15 Jul 2011 07:53 |
Last Modified: | 15 Jul 2011 07:53 |
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