Pokharkar, V. B. ; Sivaram, S. (1996) Permeability studies across poly(alkylene carbonate) membranes Journal of Controlled Release, 41 (3). pp. 157-162. ISSN 0168-3659
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Official URL: http://www.sciencedirect.com/science/article/pii/0...
Related URL: http://dx.doi.org/10.1016/0168-3659(96)01325-9
Abstract
The maximum steady state flux, diffusion coefficients and solubilities of piroxicam, a water insoluble drug and theophylline, a water soluble drug in poly(alkylene carbonate)s of varying alkyl chain lengths were determined and compared with poly(lactide)s. The permeabilities were found to be profoundly affected by the nature of the permeant as well as the polymer properties. Comparative studies in terms of overall performance with other well known systems revealed that poly(alkylene carbonate)s were more permeable than glassy poly(lactide)s and thus show potential as carriers in polymeric drug delivery systems.
| Item Type: | Article |
|---|---|
| Source: | Copyright of this article belongs to Elsevier Science. |
| Keywords: | Poly(alkylene carbonate); Permeability Coefficient; Diffusivity; Piroxicam; Theophylline |
| ID Code: | 48559 |
| Deposited On: | 14 Jul 2011 14:17 |
| Last Modified: | 14 Jul 2011 14:17 |
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