Irregular chiasm-C-roughest, a member of the immunoglobulin superfamily, affects sense organ spacing on the Drosophila antenna by influencing the positioning of founder cells on the disc ectoderm

Venugopala Reddy, G. ; Reiter, Christian ; Shanbhag, Shubha ; Fischbach, Karl-Friedrich ; Rodrigues, V. (1999) Irregular chiasm-C-roughest, a member of the immunoglobulin superfamily, affects sense organ spacing on the Drosophila antenna by influencing the positioning of founder cells on the disc ectoderm Development Genes and Evolution, 209 (10). pp. 581-591. ISSN 0949-944X

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Official URL: http://www.springerlink.com/content/9jbvyaa5vx7nyk...

Related URL: http://dx.doi.org/10.1007/s004270050292

Abstract

We describe a role for Irregular chiasmC-roughest (IrreC-rst), an immunoglobulin (Ig) superfamily member, in patterning sense organs on the Drosophila antenna. IrreC-rst protein is initially expressed homogeneously on apical profiles of ectodermal cells in regions of the antennal disc. During specification of founder cells (FCs), the intracellular protein distribution changes and becomes concentrated in regions where specific intercellular contacts presumably occur. Loss of function mutations as well as misexpression of irreC-rst results in an altered arrangement of FCs within the disc compared to wildtype. Sense organ development occurs normally, although spacing is affected. Unlike its role in interommatidial spacing, irreC-rst does not affect apoptosis during antennal development. We propose that IrreC-rst affects the spatial relationship between sensory and ectodermal cells during FC delamination.

Item Type:Article
Source:Copyright of this article belongs to Springer.
Keywords:Irregular Chiasm-C-roughest; Immunoglobulin Domain Superfamily; Adhesion Molecules; Olfactory Sense Organs; Antennal Disc
ID Code:48412
Deposited On:14 Jul 2011 06:41
Last Modified:14 Jul 2011 06:41

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