Mutations in masquerade, a novel serine-protease-like molecule, affect axonal guidance and taste behavior in Drosophila

Murugasu-Oei, Bernadette ; Balakrishnan, Rohini ; Yang, Xiaohang ; Chi, William ; Rodrigues, Veronica (1996) Mutations in masquerade, a novel serine-protease-like molecule, affect axonal guidance and taste behavior in Drosophila Mechanisms of Development, 57 (1). pp. 91-101. ISSN 0925-4773

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Official URL: http://www.sciencedirect.com/science/article/pii/0...

Related URL: http://dx.doi.org/10.1016/0925-4773(96)00537-0

Abstract

The masquerade (mas) locus encodes an extracellular molecule with a striking similarity to serine proteases. The serine residue, which is essential for enzymatic activity, has been substituted by glycine, suggesting that MAS could serve to antogonize serine protease activity [Murugasu-Oei et al. (1995), Genes Dev. 9, 139-154]. We describe the expression pattern of mas mRNA and protein in the developing embryonic, larval and pupal nervous system and in the epidermis. Total loss of mas function is lethal and results in aberrations in the embryonic central and peripheral nervous systems, consistent with a role in axonal guidance. The possibility that the observed deficits in taste behavior, exhibited by animals with partial loss of mas function, are a result of defects in the adult brain are discussed.

Item Type:Article
Source:Copyright of this article belongs to Elsevier Science.
Keywords:Drosophila; Masquerade; Axonal Guidance; Gustatory Pathways; Nervous System Development; Serine-protease-like
ID Code:48361
Deposited On:14 Jul 2011 06:41
Last Modified:14 Jul 2011 06:41

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