Sasisekharan, V. ; Gupta, Goutam ; Bansal, Manju (1981) Sequence-dependent molecular conformation of polynucleotides: right and left-handed helices International Journal of Biological Macromolecules, 3 (1). pp. 2-8. ISSN 0141-8130
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Official URL: http://linkinghub.elsevier.com/retrieve/pii/014181...
Related URL: http://dx.doi.org/10.1016/0141-8130(81)90017-9
Abstract
Based upon a stereochemical guideline, two topologically distinct types of helicalduplexes have been deduced for a polynucleotide duplex with alternating purine pyrimidine sequence (PAPP): (a) right-handed uniform (RU) helix and (b) left-handed zig-zag (LZ) helix. Both structures have trinucleoside diphosphate as the basic unit wherein the purine pyrimidine fragment has a different conformation from the pyrimidine-purine fragment. Thus, RU and LZ helices represent two different classes of sequence-dependent molecular conformations for PAPP. The conformationalf eatures of an RU helix of PAPP in B-form and three LZ-helices for B-, D- and Z-forms are discussed.
| Item Type: | Article |
|---|---|
| Source: | Copyright of this article belongs to Elsevier Science. |
| ID Code: | 48016 |
| Deposited On: | 13 Jul 2011 14:12 |
| Last Modified: | 13 Jul 2012 08:44 |
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