Vanniarajan, Ayyasamy ; Govindaraj, Periyasamy ; Justin Carlus, S. ; Aruna, Meka ; Aruna, P. ; Kumar, Ajay ; Jayakar, Richard Issac ; Lionel, Anath C. ; Gupta, Sandeep ; Rao, Lakshmi ; Gupta, Nalini J. ; Chakravarthy, Baidyanath ; Deenadayal, Mamatha ; Selvaraj, Kamala ; Andal, Sadaranga ; Mohan Reddy, B. ; Singh, Lalji ; Thangaraj, Kumarasamy (2011) Mitochondrial DNA variations associated with recurrent pregnancy loss among Indian women Mitochondrion, 11 (3). pp. 450-456. ISSN 1567-7249
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Official URL: http://www.sciencedirect.com/science/article/pii/S...
Related URL: http://dx.doi.org/10.1016/j.mito.2011.01.002
Abstract
Several genetic factors have been found to be associated with recurrent pregnancy loss (RPL). However, not many attempts have been made to associate the mitochondrial DNA (mtDNA) variations with RPL. Therefore, we have analyzed the complete mtDNA of 100 women with RPL and 12 aborted fetal tissues. Our analysis revealed a total of 681 variations, most of which were in NADH Dehydrogenase (ND) genes that encode mitochondrial enzyme Complex I. Presence of T4216C variation (ND1 gene) in 9% of the RPL women and several pathogenic, and novel mutations suggest the role of mtDNA variations in RPL.
| Item Type: | Article |
|---|---|
| Source: | Copyright of this article belongs to Elsevier Science. |
| Keywords: | Recurrent Pregnancy Loss; mtDNA; Haplogroup |
| ID Code: | 46835 |
| Deposited On: | 06 Jul 2011 06:58 |
| Last Modified: | 06 Jul 2011 06:58 |
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