Jones, K. W. ; Singh, L. (1981) Conserved repeated DNA sequences in vertebrate sex chromosomes Human Genetics, 58 (1). pp. 46-53. ISSN 0340-6717
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Official URL: http://www.springerlink.com/content/l021ppm38535h8...
Related URL: http://dx.doi.org/10.1007/BF00284148
Abstract
Satellite DNA isolated from female Elapid snakes contains nucleotide sequences which are quantitatively derived from the W sex-determining chromosome. Certain of these sequences are highly conserved in vertebrates, including mammals, where they are arranged in a sex-specific pattern in Southern blots. Sex reversed mice (Sxr) show a DNA arrangement of these sequences in conformity with their phenotypic sex, suggesting that this DNA is closely connected with the determination of sex. In situ hybridization of the snake sequences with mouse chromosomes reveals a concentration of related DNA at the proximal tip of the mouse Y chromosome. The possible nature and significance of these observations is discussed.
| Item Type: | Article |
|---|---|
| Source: | Copyright of this article belongs to Springer. |
| ID Code: | 46797 |
| Deposited On: | 06 Jul 2011 04:54 |
| Last Modified: | 06 Jul 2011 04:54 |
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