Dua, Virendra K. ; Sinha, Sukesh N. ; Biswas, Sukla ; Valecha, N. ; Puri, S. K. ; Sharma, V. P. (2002) Isolation and antimalarial activity of peroxydisulfate oxidation products of primaquine Bioorganic & Medicinal Chemistry Letters, 12 (24). pp. 3587-3589. ISSN 0960-894X
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Official URL: http://www.sciencedirect.com/science/article/pii/S...
Related URL: http://dx.doi.org/10.1016/S0960-894X(02)00802-8
Abstract
Five compounds formed by peroxydisulfate oxidation of primaquine were isolated using chromatographic methods and evaluated for antimalarial activity in vitro. One compound 6-methoxy-5,8 bis(4'-amino-1'-methylbutylamino)quinoline [P1] was found to have good gametocytocidal activity against Plasmodium yoelli infected mice at 10 mg kg−1 dose in vivo.
| Item Type: | Article |
|---|---|
| Source: | Copyright of this article belongs to Elsevier Science. |
| ID Code: | 46589 |
| Deposited On: | 05 Jul 2011 11:50 |
| Last Modified: | 05 Jul 2011 11:50 |
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