Sinha, Somdatta ; Ramaswamy, Ramakrishna (1988) Complex behaviour of the repressible operon Journal of Theoretical Biology, 132 (3). pp. 307-318. ISSN 0022-5193
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Official URL: http://www.sciencedirect.com/science/article/pii/S...
Related URL: http://dx.doi.org/10.1016/S0022-5193(88)80217-0
Abstract
The repressor-mediated repression process in bacteria is modelled using a gene-enzyme-endproduct control unit. A combined analytical-numerical study shows that the system, though stable normally, becomes unstable for super-repressing strains even at low values of the cooperativity of repression, provided demand for the endproduct saturates at large endproduct concentrations. In addition the system also shows bistability, i.e., the co-existence of a stable steady-state and a stable limit cycle. The tryptophan operon is used as a model system and the results are discussed in the light of differential regulation of gene expression in lower organisms, especially in mutant strains.
Item Type: | Article |
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Source: | Copyright of this article belongs to Elsevier Science. |
ID Code: | 45368 |
Deposited On: | 28 Jun 2011 04:42 |
Last Modified: | 28 Jun 2011 04:42 |
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