Conformation of the oligonucleotide d(AAAAAATTTTTT)2 by two-dimensional nuclear overhauser effect spectroscopy and its relevance to poly(dA) · poly(dT)

Roy, Siddhartha ; Borah, Babul ; Zon, Gerald ; Cohen, Jack S. (1987) Conformation of the oligonucleotide d(AAAAAATTTTTT)2 by two-dimensional nuclear overhauser effect spectroscopy and its relevance to poly(dA) · poly(dT) Biopolymers, 26 (4). pp. 525-536. ISSN 0006-3525

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Official URL: http://onlinelibrary.wiley.com/doi/10.1002/bip.360...

Related URL: http://dx.doi.org/10.1002/bip.360260406

Abstract

Conformational analysis from the pattern and intensities of cross-peaks in the two-dimensional nuclear Overhauser effect proton nmr spectra of the homopolymer, poly(dA) · poly(dT), and the analogous oligomer, d(AAAAAATTTTTT)2, indicate that they both exist in the B-conformation. The conformation of the ApT/TpA junction in the oligomer is significantly different from the rest of the base pairs.

Item Type:Article
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