Roy, Siddhartha ; Hiyama, Yukio ; Torchia, Dennis A. ; Cohen, Jack S. (1986) New enzymic synthesis of 2'-deoxynucleoside-2',2'-d2 and the determination of sugar ring flexibility by solid-state deuterium NMR Journal of the American Chemical Society, 108 (7). pp. 1675-1678. ISSN 0002-7863
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Official URL: http://pubs.acs.org/doi/abs/10.1021/ja00267a043
Related URL: http://dx.doi.org/10.1021/ja00267a043
Abstract
An enzymatic synthesis of nucleosides selectively deuterated in the deoxyribose ring is described. The method is illustrated with the synthesis of 2'-deoxyguanosine-2',2'-d2 and thymidine-2',2'-d2. The availability of such labeled nucleosides enables the motional characteristics of the deoxyribose ring to be investigated with deuterium NMR spectroscopy in solution and the solid state.
| Item Type: | Article |
|---|---|
| Source: | Copyright of this article belongs to American Chemical Society. |
| ID Code: | 43149 |
| Deposited On: | 10 Jun 2011 06:15 |
| Last Modified: | 10 Jun 2011 06:15 |
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