Jagannadha Rao, A. ; Prasad, K. S. S. ; Sharma, S. C. ; Subbarayan, V. S. R. (1995) Role of 17β-estradiol and progesterone in the regulation of synthesis and secretion of chorionic gonadotropin by the first trimester human placenta The Journal of Steroid Biochemistry and Molecular Biology, 53 (1-6). pp. 233-239. ISSN 0960-0760
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Official URL: http://linkinghub.elsevier.com/retrieve/pii/096007...
Related URL: http://dx.doi.org/10.1016/0960-0760(95)00053-3
Abstract
The role of 17β-estradiol and progesterone in the regulation of synthesis of chorionic gonadotropin (CG) by first trimester human placenta has been studied using 1,4,6 androstatriene 3-17-dione to block the synthesis of 17β-estradiol or tamoxifen to block its action at receptor level and RU486 to block the action of progesterone at the receptor level. Results indicate that the synthesis of CG is negatively modulated by 17β-estradiol and positively modulated by progesterone as judged by the change in the levels of immunoreactive CG, α- and β-CG mRNA and in vitro translation, as well as biosynthesis of α- and β-CG and, finally, nuclear run off transcription.
Item Type: | Article |
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Source: | Copyright of this article belongs to Elsevier Science. |
ID Code: | 43029 |
Deposited On: | 09 Jun 2011 09:03 |
Last Modified: | 09 Jun 2011 09:03 |
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