Adrenocorticotropin 52. Synthesis and biological activity of adrenocorticotropic peptides with cystine bridges

Blake, James ; Jagannadha Rao, A. ; Li, Choh Hao (1979) Adrenocorticotropin 52. Synthesis and biological activity of adrenocorticotropic peptides with cystine bridges International Journal of Peptide and Protein Research, 13 (3). pp. 346-352. ISSN 0367-8377

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Official URL: http://onlinelibrary.wiley.com/doi/10.1111/j.1399-...

Related URL: http://dx.doi.org/10.1111/j.1399-3011.1979.tb01891.x

Abstract

Three analogs of the amino terminal nonadecapeptide of adrenocorticotropin which incorporate cystine bridges between positions (5, 10), (3, 10), or (2, 10) have been synthesized. All of the peptide analogs showed reduced biological activity; however, the peptide with the 5, 10 cystine bridge was shown to possess significantly higher lipolytic activity in rat fat cells than the peptides with a 3, 10 or 2, 10 cystine bridge.

Item Type:Article
Source:Copyright of this article belongs to Munksgaard International Publishers.
Keywords:ACTH; Cyclic Peptides; Cystine Bridges; Lipolytic Activity; Steroidogenic Activity
ID Code:43004
Deposited On:09 Jun 2011 07:46
Last Modified:09 Jun 2011 07:46

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