Regulation of low density lipoprotein receptor mRNA levels by estradiol 17β and chorionic gonadotropin in human placenta

Gopi Shanker, Y. ; Shetty, Usha P. ; Jagannadha Rao, A. (1998) Regulation of low density lipoprotein receptor mRNA levels by estradiol 17β and chorionic gonadotropin in human placenta Molecular and Cellular Biochemistry, 187 (1-2). pp. 133-139. ISSN 0300-8177

Full text not available from this repository.

Official URL: http://www.springerlink.com/content/w09h727w58nq6k...

Related URL: http://dx.doi.org/10.1023/A:1006843812495

Abstract

Inhibition of synthesis of estradiol 17β by the addition of inhibitors of aromatase, a key enzyme in the biosynthesis of estradiol 17β , or addition of tamoxifen- an estrogen receptor antagonist, to human placental minces resulted in an increase in the level of LDL-receptor mRNA. This increase could be blocked by the simultaneous addition of estradiol 17β . A concentration dependent effect of estradiol 17β on the level of LDL-receptor mRNA was seen both in first trimester, and term placenta. Addition of human chorionic gonadotropin (hCG) to term placental minces also increased the LDL-receptor mRNA levels. When hCG and cycloheximide were added together, an additive effect was observed. The results obtained in this study suggest that the LDL-receptor mRNA levels in the human placenta are regulated by estradiol 17β and hCG.

Item Type:Article
Source:Copyright of this article belongs to Springer.
Keywords:LDL-receptor; Estradiol 17β; Human Chorionic Gonadotropin; Human Placenta; Progesterone Synthesis
ID Code:42984
Deposited On:08 Jun 2011 13:17
Last Modified:08 Jun 2011 13:17

Repository Staff Only: item control page